Injecting the enzyme Collagenase - injecting an enzyme causing the destruction of collagen composing the connective tissue. Recently the enzyme Collagenase is also injected into the ligament area. The enzyme contains proteins causing the breaking and weakening of bonds inside the ligament tissue. 24 hours after the injection, under local anesthesia, the physician performs a stretching of the fingers and tearing of the treated ligaments until the fingers are straightened. In some cases there is need to use a splint to hold the finger in its straight position until full recovery is achieved.


It is strictly forbidden to perform the action of straightening the finger, pulling or pressing it independently by the patient. Keeping the finger's bent position helps the active ingredient which was injected into it to do its job.


In case the initial injection was not effective it is possible to repeat it one month after the initial injection and up to three injections in total.


The injected enzyme is certified for use in Europe and the United States but is not certified by the Israeli Ministry of Health. It is possible to import it by Form 29ג of the Ministry of Health, signed by the physician or pharmacy.


Advantages - alternative treatment to surgery with all its implications, such as: complications and long-term recovery.


Disadvantages - this process does not suit every person. There are risk factors such as: anaphylactic shock, blood coagulation problems, pregnancy, age.


Side Effects - swelling, bleeding and internal bleeding, pain, inflammation – these side effects typically disappear within a few days.


At this stage, it is only possible to treat one finger with a waiting time of one month between treatments.

Enzyme Collagenase e e e

"Shiba" Medical Center Tel HashomerHand surgery department

Ramat GanShai Medical Center– Private Medical Service Tel Hashomer, 4th Gildsgaim St.

Kfar Saba: Eli Horowitz 12.

Postal AddressDr. Alon Covo, 10th HaGanim St.

P.O. Box 3824 Hod Hasharon 4522174.


Appointments and messages054-7232194

מרכז רפואי "שיבא" תל השומר: המחלקה לכירורגיה של היד

מרפאת רמת גן: מרכז רפואי שי- שר"פ תל השומר, רחוב גילדסגיים 4.

מרפאת כפר סבא: מדיקל השרון- רחוב אלי הורביץ 12.

כתובת למשלוח דואר: ד"ר אלון קובו, רחוב הגנים 10 ת.ד. 3824,

הוד השרון, 4522174


טלפון לזימון תורים והשארת הודעות: 054-7232194

המידע, העצות והתרגילים באתר הינם כללים וחלקיים בלבד ואינם באים להחליף יעוץ אישי מקצועי של רופא.

ד"ר קובו אינו אחראי לנזק שיגרם עקב הסתמכות על מידע זה, ולהתאמת או אי התאמת המידע, העצות והטיפולים לכל מטופל. המידע, העצות והתרגילים אינם מהווים תחליף או תוספת לפרוטוקול הרפואי.

המידע המובא באתר הינו כללי ומשותף לכלל הגולשים ולא חלה עליו סודיות מידע. בכל מקרה של סיבוך באזור הכאב או ספק או שאלה לגבי המידע שניתן באתר, יש לפנות מיד לרופא המטפל.

The information, advice and practices given in this web page are general and partial only and do not seek to replace professional personal advice given by a physician.

Dr. Covo bears no responsibility to any damage caused based on this information or to the degree in which the information, advice and treatment fit each and every patient. The information, advice and practices do not come as replacement or addition to the medical protocol. The information given in this site is general and common to all visitors and is not subject to confidentiality

In any case of complication in the area of the pain, of doubt or question about the information given in this web page, it is important to contact the treating physician immediately.